تفاعل #1121743

معادلة التفاعل

Boc-threonine

glycine ethyl ester hydrochloride

triethylamine

N,N′-dicyclohexylcarbodiimide

hydroxybenzotriazole

→

Boc-Thr-Gly-OEt

المردود 85.4%

المذيبات

dichloromethane

ظروف التفاعل

المعالجة

1. 1
   أخرىthe mixture was reacted at room temperature for overnight
2. 2
   أخرىAfter completion of the reaction, reaction mixture
3. 3
   ترشيحwas filtered
4. 4
   استخلاصthe filtrate was extracted with ethyl acetate
5. 5
   تركيزThe extract was concentrated under reduced pressure
6. 6
   أخرىthe product was crystallized from hexane

الإجراء التجريبي

Boc-threonine (produced by Wako Pure Chemical Industries Ltd.) (11.0 g, 50 mmol) and glycine ethyl ester hydrochloride (produced by Wako Pure Chemical Industries Ltd.) (8.4 g, 60 mmol) were dissolved in dichloromethane (250 mL). After triethylamine (8.4 mL, 60 mmol), N,N′-dicyclohexylcarbodiimide (DCC, 12.4 g, 60 mmol) and hydroxybenzotriazole (9.2 g, 60 mmol) were further added thereto, the mixture was reacted at room temperature for overnight with stirring. After completion of the reaction, reaction mixture was filtered, and then the filtrate was extracted with ethyl acetate. The extract was concentrated under reduced pressure, and the product was crystallized from hexane, to obtain Boc-Thr-Gly-OEt (1) (13.0 g) (yield; 85.1%).

المصدر