تفاعل #1121718

معادلة التفاعل

acetophenone

4-tert-butylbenzoyl chloride

→

1-phenylvinyl 4-tert-butylbenzoate

المردود 57.0%

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   workup.WAITThe mixture was then left
2. 2
   درجة الحرارةto cool
3. 3
   استخلاصextracted with dichloromethane
4. 4
   تجفيفThe organic phase was dried over magnesium sulfate
5. 5
   أخرىthe solvent was removed under reduced pressure
6. 6
   أخرىA 2.12 g sample was purified by flash chromatography (hexane:dichloromethane 3:1)

الإجراء التجريبي

A mixture of 4.16 g (21.62 mmol) of acetophenone trimethylsilylenol, 4.33 g (22.01 mmol) of 4-tert-butylbenzoyl chloride and 136 mg of mercuric chloride was heated at 100° C. for 2 h. The mixture was then left to cool, water was added over the reaction crude and extracted with dichloromethane. The organic phase was dried over magnesium sulfate and the solvent was removed under reduced pressure. A 2.12 g sample was purified by flash chromatography (hexane:dichloromethane 3:1) giving 1.17 g of 1-phenylvinyl 4-tert-butylbenzoate. Yield 57%.

المصدر