تفاعل #1121716

معادلة التفاعل

hydroquinone

1,6-dibromo hexane

Potassium hydroxide

→

4-(6-bromohexyloxy)phenol

المردود 39.4%

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   أخرىfluxed at 60° C.
2. 2
   أخرى(Celsius) overnight
3. 3
   أخرىis lowered to a room temperature
4. 4
   أخرىmethanol was evaporated from the reaction mixture
5. 5
   استخلاصThen, the reaction mixture was extracted three times with water (100 ml (milliliters)) and ethyl acetate (100 ml (milliliters))
6. 6
   أخرىWater was removed over magnesium sulfate
7. 7
   أخرىthe solvents were evaporated
8. 8
   أخرىthe resulting reaction mixture
9. 9
   أخرىwas purified

الإجراء التجريبي

As shown in the following Scheme, hydroquinone (1) (4.5 g (grams)) and 1,6-dibromo hexane (2) (10 g (grams)) were dissolved in methanol (100 ml (milliliters)) at a room temperature. Potassium hydroxide (2.3 g (grams)) was added to the resulting mixture solution, and then fluxed at 60° C. (Celsius) overnight. Next day, the temperature of the reaction mixture is lowered to a room temperature, and methanol was evaporated from the reaction mixture. Then, the reaction mixture was extracted three times with water (100 ml (milliliters)) and ethyl acetate (100 ml (milliliters)). Water was removed over magnesium sulfate, and the solvents were evaporated, and the resulting reaction mixture was purified using a column chromatography (developer solution: ethylacetate/hexane=1/5 volume ratio) to obtain 4.4 g (grams) of 4-(6-bromohexyloxy)phenol (3).

المصدر