تفاعل #1117305

ord-29c2345b54064b849067dc0549464969

معادلة التفاعل

C[N+]1(C)CCC(S)CC1
1,1-dimethyl-4-mercaptopiperidinium
C[C@@H](O)[C@H]1C(=O)N2C(C(=O)OCc3ccc([N+](=O)[O-])cc3)C(=O)C[C@H]12
4-nitrobenzyl (5R, 6S)-6-[(1R)-1-hydroxyethyl]-2-oxo-1-carbapenam-3-carboxylate
→
C[C@@H](O)[C@H]1C(=O)N2C(C(=O)[O-])=C(SC3CC[N+](C)(C)CC3)C[C@H]12
title compound
المردود 6.8%
C[C@@H](O)[C@H]1C(=O)N2C(C(=O)[O-])=C(SC3CC[N+](C)(C)CC3)C[C@H]12
(5R, 6S)-2-[1,1-Dimethylpiperidinium-4-ylthio]-6-[(1R)-1-hydroxyethyl]-1-carbapen-2-em-3-carboxylate
المردود 6.8%

المتفاعلات

C[N+]1(C)CCC(S)CC1
1,1-dimethyl-4-mercaptopiperidinium
C[C@@H](O)[C@H]1C(=O)N2C(C(=O)OCc3ccc([N+](=O)[O-])cc3)C(=O)C[C@H]12
4-nitrobenzyl (5R, 6S)-6-[(1R)-1-hydroxyethyl]-2-oxo-1-carbapenam-3-carboxylate

الكواشف

لا شيء

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

المعالجة

  1. 1
    أخرىprepared

الإجراء التجريبي

Following a procedure similar to that described in Example 6, but using 368 mg of the crude 1,1-dimethyl-4-mercaptopiperidinium salt prepared as described in Example 7-(1) and, 363 mg of 4-nitrobenzyl (5R, 6S)-6-[(1R)-1-hydroxyethyl]-2-oxo-1-carbapenam-3-carboxylate, 24 mg of the title compound were obtained.

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US05104867uspto-grants-1992_04