تفاعل #11168

معادلة التفاعل

(2,6-dichloro-3-methoxyphenyl)methanol

HBr

bromide

triphenylphosphine

→

phosphonium

المردود 97.0%

(2,6-Dichloro-3-methoxybenzyl)(triphenyl)phosphonium bromide

المردود 97.0%

المذيبات

acetic acid

CH2Cl2 benzene

ظروف التفاعل

الإجراء التجريبي

Bromination of (2,6-dichloro-3-methoxyphenyl)methanol with 30% HBr in acetic acid, followed by reaction of the crude bromide with triphenylphosphine, using the procedure described in example 112, except that the reaction time for the displacement was 36 h, gave the phosphonium salt (526) (97%) as a white solid, mp (CH2Cl2/benzene) 242–244° C. 1H NMR (CDCl3) δ 7.83–7.60 (m, 15H), 7.15 (dd, J=9.1, 0.8 Hz, 1H), 6.88 (dd, J=9.0, 2.4 Hz, 1H), 5.41 (d, J=14.3 Hz, 2H), 3.84 (s, 3H). Found: C, 58.68; H, 4.16. C26H22BrCl2OP requires C, 58.67; H, 4.17.

المصدر