تفاعل #1111207

معادلة التفاعل

compound 104b

6-Chloro-N-(5-(4-methylpiperazin-1-yl)pyridin-2-yl)imidazo[1,2-b]pyridazin-8-amine

8-bromo-6-chloroimidazo[1,2-b]pyridazine

8-Bromo-6-chloroimidazo[1,2-b]pyridazine

5-(4-(oxetan-3-yl)piperazin-1-yl)pyridin-2-amine

→

105a

المردود 77.0%

6-Chloro-N-(5-(4-(oxetan-3-yl)piperazin-1-yl)pyridin-2-yl)imidazo[1,2-b]pyridazin-8-amine

المردود 77.0%

ظروف التفاعل

المعالجة

1. 1
   أخرىwere reacted

الإجراء التجريبي

Following the procedures as described for compound 104b, 8-bromo-6-chloroimidazo[1,2-b]pyridazine 104a (233 mg, 1.0 mmol), and 5-(4-(oxetan-3-yl)piperazin-1-yl)pyridin-2-amine (234 mg, 1.0 mmol) were reacted to give 105a as a white solid (296 mg, 77%). LCMS: [M+H]+ 386

المصدر