تفاعل #1108434

معادلة التفاعل

Water

1-[3-({[tert-Butyl(dimethyl)silyl]oxy}methyl)-2-fluorophenyl]-3-methoxyazetidine

THF

TBAF THF

→

[2-fluoro-3-(3-methoxyazetidin-1-yl)phenyl]methanol

المردود 91.7%

المذيبات

EtOAc

ظروف التفاعل

المعالجة

1. 1
   تجفيفthe organic layer was dried over Na2SO4
2. 2
   تركيزconcentrated under reduced pressure
3. 3
   أخرىThe obtained residue was purified by silica gel column chromatography

الإجراء التجريبي

1-[3-({[tert-Butyl(dimethyl)silyl]oxy}methyl)-2-fluorophenyl]-3-methoxyazetidine (121 mg) was mixed with THF (4 ml), and a 1 M TBAF/THF solution (0.8 ml) was added thereto, followed by stirring at room temperature for 1 hour. Water and EtOAc were added to the reaction mixture, and the organic layer was dried over Na2SO4 and concentrated under reduced pressure. The obtained residue was purified by silica gel column chromatography to obtain [2-fluoro-3-(3-methoxyazetidin-1-yl)phenyl]methanol (72 mg).

المصدر