تفاعل #1106675

معادلة التفاعل

3-bromo-5-tert-butylbenzaldehyde

malonic acid

ammonium acetate

→

product

المردود 51.6%

3-amino-3-(3-bromo-5-tert-butylphenyl)propionic acid

المردود 51.6%

المذيبات

isopropanol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwas heated
2. 2
   درجة الحرارةat reflux under nitrogen for 3 h
3. 3
   أخرىto afford a thick colorless solid
4. 4
   ترشيحThe solid was filtered hot
5. 5
   غسيلwashed with hot isopropanol (2×25 mL)
6. 6
   أخرىdried in vacuo

الإجراء التجريبي

A suspension of 3-bromo-5-tert-butylbenzaldehyde (4.17 g, 17.30 mmol), malonic acid (2.15 g, 20.72 mmol) and ammonium acetate (2.66 g, 34.59 mmol) in isopropanol (35 mL) was heated at reflux under nitrogen for 3 h to afford a thick colorless solid. The solid was filtered hot, washed with hot isopropanol (2×25 mL) and dried in vacuo to give the desired racemic product as a colorless solid (2.68 g).

المصدر