تفاعل #1106642

معادلة التفاعل

NaOH

1-(2-hydroxy-4-(methoxymethoxy)phenyl)-3-(6-methoxypyridin-3-yl)propan-1-one

TFA

→

white solid

المردود 35.8%

2,4-dihydroxyphenyl-3-(6-methoxypyridin-3-yl)propan-1-one

المردود 35.8%

المذيبات

CH3CN

ظروف التفاعل

المعالجة

1. 1
   استخلاصThe aqueous was extracted with 100 ml EtOAc
2. 2
   غسيلThe organic layer was washed with brine
3. 3
   تجفيفdried (Na2SO4)
4. 4
   تركيزconcentrated
5. 5
   أخرىThe residue was purified by silica gel chromatography (15% EtOAc/Hexane)

الإجراء التجريبي

To a solution of 1-(2-hydroxy-4-(methoxymethoxy)phenyl)-3-(6-methoxypyridin-3-yl)propan-1-one (1.62 g, 5.11 mmol) in CH3CN (30 ml) at room temperature was added TFA (2 ml) dropwise, two drops of water. The reaction was stirred at same temperature for 8 h. Aqueous 1N NaOH was added to the reaction mixture until pH=7. The aqueous was extracted with 100 ml EtOAc, and the organic layers were combined. The organic layer was washed with brine, dried (Na2SO4) and concentrated. The residue was purified by silica gel chromatography (15% EtOAc/Hexane) to provide 0.5 g (35%) of white solid.

المصدر