تفاعل #11044

معادلة التفاعل

Methyl (2S)-3-(3′-amino[1,1′-biphenyl]-4-yl)-2-mesitylsulfonylamino-propanoate

3,4-diethoxy-3-cyclobuten-1,2-dion

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title compound

المردود 59.0%

Methyl (2S)-3-{3′-[(2-ethoxy-3,4-dioxo-1-cyclobuten-1-yl)-amino][1,1′-biphenyl]-4-yl}-2-mesitylsulfonylamino-propanoate

المردود 59.0%

المذيبات

1 propanol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةrefluxed for 20 h
2. 2
   أخرىPurification by flash chromatography (dichloromethane/acetic acid ethyl ester 10+1)

الإجراء التجريبي

2 g of Methyl (2S)-3-(3′-amino[1,1′-biphenyl]-4-yl)-2-mesitylsulfonylamino-propanoate 12.1.2 were mixed with 0.75 g 3,4-diethoxy-3-cyclobuten-1,2-dion in 40 ml 1 propanol and refluxed for 20 h. Purification by flash chromatography (dichloromethane/acetic acid ethyl ester 10+1) yielded 1,5 g of the title compound.

المصدر