تفاعل #1095862

معادلة التفاعل

4-chloro-5-fluoro-6-(2-pentynyloxy)pyrimidine

piperidine

→

5-fluoro-4-piperidino-6-(2-pentynyloxy)pyrimidine

المردود 97.8%

ظروف التفاعل

الإجراء التجريبي

0.2 g of 4-chloro-5-fluoro-6-(2-pentynyloxy)pyrimidine and 0.24 g of piperidine were mixed and left for 3 hours at room temperature. The reaction mixture was subjected to silica gel column chromatography to obtain 0.24 g of 5-fluoro-4-piperidino-6-(2-pentynyloxy)pyrimidine (hereinafter, referred to as Compound (12)).

المصدر