تفاعل #1095846

معادلة التفاعل

ethyl acrylate

ethyl glycinate hydrochloride

sodium hydroxide

→

Diethyl-2-azabutane-1,4-dicarboxylate

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   أخرىAfter 19 h the solution was partitioned with dichloromethane (3×100 mL)
2. 2
   تجفيفThe organic layer was dried with anhydrous sodium sulfate
3. 3
   ترشيحfiltered
4. 4
   أخرىevaporated
5. 5
   workup.DISTILLATIONThe residue was distilled
6. 6
   أخرىto afford AA (28.8 g, 61%)

الإجراء التجريبي

A 4.7 M aqueous solution of sodium hydroxide (50 mL) was added into a stirred, ice-cooled solution of ethyl glycinate hydrochloride (32.19 g, 0.23 mole) in water (50 mL). Then, ethyl acrylate (23.1 g, 0.23 mole) was added and the mixture was stirred at room temperature until completion of the reaction was ascertained by TLC. After 19 h the solution was partitioned with dichloromethane (3×100 mL). The organic layer was dried with anhydrous sodium sulfate, filtered and evaporated. The residue was distilled to afford AA (28.8 g, 61%).

المصدر