تفاعل #1095841

معادلة التفاعل

compound 1

3-Iodocarbazole

acrylonitrile

triphenylphosphine

triethylamine

→

compound 2

المردود 18.0%

3-Cyanovinylcarbazole

المردود 18.0%

compound 1

المردود 37.0%

3-Iodocarbazole

المردود 37.0%

المذيبات

AcOEt

HexH

dioxane

dioxane

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةthe reaction solution was refluxed for 11.5 hours
2. 2
   أخرىthe palladium powder was removed by cotton filtration
3. 3
   أخرىThe product was purified by column chromatography (HexH:AcOEt=4:1)

الإجراء التجريبي

To a dioxane solution (10 mL) of triphenylphosphine (139 mg, 0.53 μmol), palladium acetate (40.0 mg, 0.18 μmol) and triethylamine (0.59 μL, 4.23 mmol) were sequentially added, and the mixture was stirred for 5 minutes at 75° C. A dioxane solution (15 mL) of compound 1 (1.03 g, 3.52 mmol) and acrylonitrile (0.46 μL, 7.04 mmol) were added, and the reaction solution was refluxed for 11.5 hours. The product was confirmed by TLC (HexH:AcOEt=4:1), and then the palladium powder was removed by cotton filtration. The product was purified by column chromatography (HexH:AcOEt=4:1), and compound 2 (0.14 g, 18%, trans:cis=97:3) was obtained as a white powder, while compound 1 (0.37 g, recovery rate 37%) was recovered as a white powder.

المصدر