تفاعل #1094558

معادلة التفاعل

6-bromo-2-indolinone

phenylboric acid

sodium carbonate

→

6-phenyl-2-indolinone

المذيبات

ethanol

dimethoxyethane

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONare added dropwise at ambient temperature
2. 2
   درجة الحرارةAfter cooling the catalyst
3. 3
   ترشيحis filtered off
4. 4
   غسيلthe residue is washed with 100 ml of water and 20 ml of 1N sodium hydroxide solution
5. 5
   أخرىThe residue is purified through a silica gel column with petroleum ether/ethyl acetate (8:2) as eluant

الإجراء التجريبي

2.4 g of 6-bromo-2-indolinone are placed in 60 ml of dimethoxyethane, 1.9 g of phenylboric acid in 8 ml of ethanol and 0.3 g of tetrakistriphenylphosphine palladium are added and to this mixture 12 ml of 2N sodium carbonate solution are added dropwise at ambient temperature. The mixture is stirred for 6 hours at 85° C. After cooling the catalyst is filtered off, the solvent is eliminated and the residue is washed with 100 ml of water and 20 ml of 1N sodium hydroxide solution. The residue is purified through a silica gel column with petroleum ether/ethyl acetate (8:2) as eluant.

المصدر