تفاعل #1091464

معادلة التفاعل

21-7

7-[(5,6,7,8-Tetrahydro-[1,8]naphthyridin-2-ylmethyl)-amino]-3-(quinolin-3-yl)-heptanoic acid methyl ester

NaOH

→

21-8

7-[(5,6,7,8-Tetrahydro-[1,8]naphthyridin-2-ylmethyl)-amino]-3-(quinolin-3-yl)-heptanoic acid

المذيبات

EtOH

ظروف التفاعل

المعالجة

1. 1
   أخرىthe solvents were evaporated
2. 2
   أخرىthe residue was chromatographed (silica gel, 20:10:1:1 followed by 15:10:1:1 ethyl acetate/EtOH/water NH4OH)

الإجراء التجريبي

To a solution of 21-7 (0.8255 mmol) in EtOH (5 mL) was added 1N NaOH (1.0 ml, 1.0 mmol). After stirring for 1 hour, the solvents were evaporated and the residue was chromatographed (silica gel, 20:10:1:1 followed by 15:10:1:1 ethyl acetate/EtOH/water NH4OH) to give 21-8 as a white solid.

المصدر