تفاعل #10887

معادلة التفاعل

1-(4-nitrophenyl)piperazine

potassium carbonate

iodocyclopentane

18-crown-6

→

1-cyclopentyl-4-(4-nitrophenyl)piperazine

المذيبات

acetonitrile

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةat reflux overnight
2. 2
   ترشيحThe mixture was filtered
3. 3
   غسيلthe filter cake was washed with acetonitrile
4. 4
   أخرىThe solvent was evaporated from the combined filtrates
5. 5
   أخرىthe residue was partitioned between water and ethyl acetate
6. 6
   أخرىThe layers were separated
7. 7
   استخلاصthe aqueous layer was extracted twice with ethyl acetate
8. 8
   تجفيفThe combined organic layers were dried (Na2SO4)
9. 9
   ترشيحfiltered
10. 10
    أخرىevaporated to a yellow solid
11. 11
    أخرىdried under vacuum

الإجراء التجريبي

A mixture of 1-(4-nitrophenyl)piperazine (12 g, 57.9 mmol) (Acros Organics), powdered potassium carbonate (5.4 g, 39 mmol), iodocyclopentane (7 mL, 60.8 mmol) (Aldrich) and a catalytic amount of 18-crown-6 in acetonitrile (90 mL) was heated at reflux overnight. The mixture was filtered, and the filter cake was washed with acetonitrile. The solvent was evaporated from the combined filtrates and the residue was partitioned between water and ethyl acetate. The layers were separated and the aqueous layer was extracted twice with ethyl acetate. The combined organic layers were dried (Na2SO4), filtered, evaporated to a yellow solid and dried under vacuum to give 1-cyclopentyl-4-(4-nitrophenyl)piperazine) (6.6 g, 41%.)

المصدر