تفاعل #10864

معادلة التفاعل

2-(2,6-dichloro-4-trifluoromethylphenylhydrazino)succinonitrile

→

5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole

المذيبات

chlorobenzene

ظروف التفاعل

المعالجة

1. 1
   ترشيحAfter filtration and evaporation

الإجراء التجريبي

A mixture of 2-(2,6-dichloro-4-trifluoromethylphenylhydrazino)succinonitrile (0.323 g) and cupric chloride (0.175 g) was heated in chlorobenzene at 60° C. for 6 hours. After filtration and evaporation, the title compound and 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole were obtained as a 7:1 mixture. Column chromatography on silica gel eluting with dichloromethane gave the pure title compound, obtained as a mixture of syn and anti isomers, NMR (anti isomer) 3.6 (s, 2H), 7.57 (s, 2H), 8.82 (s, 1H, exchangeable with D2O), NMR (syn isomer) 3.56 (s, 2H), 7.59 (s, 2H), 8.27 (s, 1H, exchangeable with D2O).

المصدر