تفاعل #1074580

معادلة التفاعل

biphenyl-3,4-diamine

MeOH

water

cyanogen bromide

→

5-Phenyl-1H-benzoimidazol-2-ylamine

المذيبات

THF

ظروف التفاعل

المعالجة

1. 1
   أخرىThe reaction was partitioned between EtOAc and aqueous sodium hydroxide
2. 2
   استخلاصthe aqueous layer re-extracted with EtOAc

الإجراء التجريبي

To a solution of biphenyl-3,4-diamine (0.99 mmol) in THF:MeOH:water (5 mL:10 mL:10 mL) was added cyanogen bromide (5M solution in acetonitrile, 1.06 mmol). The resulting mixture was stirred at room temperature overnight. The reaction was partitioned between EtOAc and aqueous sodium hydroxide and the aqueous layer re-extracted with EtOAc.

المصدر