تفاعل #1074027

معادلة التفاعل

3-methoxy-5-isobutoxy-phenol

1,3-dichloro-3-methyl-butane

DDQ

→

desired compound

المردود 69.0%

5-methoxy-7-isobutoxy-2,2-dimethyl-2H-chromene

المردود 69.0%

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe mixture is cooled
2. 2
   أخرىthe solvent removed
3. 3
   درجة الحرارةThe mixture is heated
4. 4
   ترشيحThe solution is filtered
5. 5
   أخرىthe filtrate evaporated
6. 6
   أخرىthe residue purified

الإجراء التجريبي

A mixture of 3.9 g (20 millimoles) of 3-methoxy-5-isobutoxy-phenol, 2.8 g (20 millimoles) of 1,3-dichloro-3-methyl-butane and 0.26 g (1 millimole) of bis-(acetyl-acetonato)-nickel is heated at 125° C. for 8 hours. The mixture is cooled, the solvent removed, the residue taken up in 40 ml of anhydrous benzene and 0.8 g (3.5 millimoles) of DDQ (dichloro-dicyano-benzoquinone) are added. The mixture is heated to boiling for 60 hours. The solution is filtered, the filtrate evaporated and the residue purified as described in Example 3. Thus 3.6 of the desired compound are obtained in the form of a colorless oil, yield 69%.

المصدر