تفاعل #1069765

معادلة التفاعل

Na2CO3

2-hydrazinopyridine

benzoylacetonitrile

→

1-pyridyl-3-phenyl-5-aminopyrazole

المردود 80.5%

المذيبات

hydrochloric acid

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe mixture was refluxed for 3 hrs
2. 2
   درجة الحرارةAfter cooling
3. 3
   ترشيحThe yellow precipitate was filtrated
4. 4
   غسيلwashed with H2O
5. 5
   أخرىdried

الإجراء التجريبي

To a solution of 1.09 g 2-hydrazinopyridine in 10 ml 5N hydrochloric acid was added 1.45 g benzoylacetonitrile (from Example 2) under stirring. The mixture was refluxed for 3 hrs. After cooling, the solution was neutralized with Na2CO3. The yellow precipitate was filtrated, washed with H2O, and dried to get 1.9 g 1-pyridyl-3-phenyl-5-aminopyrazole.

المصدر