تفاعل #10688

ord-5c825aac16db4c78bc62bbf1ee6b3093

معادلة التفاعل

Cl
hydrochloric acid
Cc1cnc(O)c2cccc(N[C@H]3CC[C@H](NC(=O)OC(C)(C)C)CC3)c12
Intermediate 140
Cc1cnc(O)c2cccc(N[C@H]3CC[C@H](NC(=O)OC(C)(C)C)CC3)c12
trans-N-(1-hydroxy-4-methyl-5-isoquinolyl)-N′-(tert-butoxycarbonyl)-1,4-cyclohexanediamine
→
Cc1cnc(O)c2cccc(N[C@H]3CC[C@H](N)CC3)c12.Cl
title compound
Cc1cnc(O)c2cccc(N[C@H]3CC[C@H](N)CC3)c12.Cl
trans-N-(1-hydroxy-4-methyl-5-isoquinolyl)-1,4-cyclohexanediamine hydrochloride

المتفاعلات

Cl
hydrochloric acid
Cc1cnc(O)c2cccc(N[C@H]3CC[C@H](NC(=O)OC(C)(C)C)CC3)c12
Intermediate 140
Cc1cnc(O)c2cccc(N[C@H]3CC[C@H](NC(=O)OC(C)(C)C)CC3)c12
trans-N-(1-hydroxy-4-methyl-5-isoquinolyl)-N′-(tert-butoxycarbonyl)-1,4-cyclohexanediamine

الكواشف

لا شيء

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

الإجراء التجريبي

According to the method of Step A of this example, deprotection with concentrated hydrochloric acid was performed by using Intermediate 140 to obtain the title compound.

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US07094789B2uspto-grants-2006_08