تفاعل #1065501

معادلة التفاعل

hydrochloric acid

3-hydroxy-5-(benzo[b]furan-2-yl)-2-butyryl cyclohex-2-en-1-one

ethoxyamine hydrochloride

sodium acetate

→

2-[1-(ethoxyimino)butyl]-3-hydroxy-5-(benzo[b]furan-2-yl)cyclohex-2-en-1-one

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   استخلاصwas then extracted with ether
2. 2
   أخرىEvaporation of the
3. 3
   أخرىdried
4. 4
   أخرى(MgSO4) organic fraction and purification of the residue by column chromatography over silica
5. 5
   غسيلwith dichloromethane elution

الإجراء التجريبي

A mixture of 3-hydroxy-5-(benzo[b]furan-2-yl)-2-butyryl cyclohex-2-en-1-one (1.0 g), ethoxyamine hydrochloride (0.36 g), sodium acetate (0.3 g) and ethanol (100 ml) were stirred at room temperature for 12 hr. The mixture was poured into a very dilute aqueous hydrochloric acid solution which was then extracted with ether. Evaporation of the dried (MgSO4) organic fraction and purification of the residue by column chromatography over silica with dichloromethane elution gave 2-[1-(ethoxyimino)butyl]-3-hydroxy-5-(benzo[b]furan-2-yl)cyclohex-2-en-1-one as a yellow solid, mp 70° C.

المصدر