تفاعل #1062136

معادلة التفاعل

3,4-dihydro-N-(phenylmethyl)-2H-1-benzopyran-2-methanamine

4-bromobutanenitrile

N,N-dimethylformamide

→

(±)-4-[[(3,4-dihydro-2H1-benzopyran-2-yl)methyl]-(phenylmethyl) amino]-butanenitrile

المردود 69.6%

المذيبات

N,N-diethylethanamine

ظروف التفاعل

المعالجة

1. 1
   أخرىThe reaction mixture was evaporated
2. 2
   أخرىthe residue was partitioned between 1,1'-oxybisethane and water
3. 3
   أخرىThe organic layer was separated
4. 4
   أخرىdried
5. 5
   ترشيحfiltered
6. 6
   أخرىevaporated

الإجراء التجريبي

A mixture of 12.5 g of 3,4-dihydro-N-(phenylmethyl)-2H-1-benzopyran-2-methanamine, 9 g of 4-bromobutanenitrile, 200 ml of N,N-dimethylformamide and 10 ml of N,N-diethylethanamine was stirred for 72 hour at room temperature. The reaction mixture was evaporated and the residue was partitioned between 1,1'-oxybisethane and water. The organic layer was separated, dried, filtered and evaporated, yielding 11 g (68.7%) of (±)-4-[[(3,4-dihydro-2H1-benzopyran-2-yl)methyl]-(phenylmethyl) amino]-butanenitrile (interm. 53).

المصدر