تفاعل #1062133

معادلة التفاعل

N,N,N-trimethylbenzenemethanaminium hydroxide

(±)-3,4-dihydro-N-(phenylmethyl)-2H-1-benzopyran-2-methanamine

1,1'-oxybisethane

→

(±)-3-[[(3,4-dihydro-2H1-benzopyran-2-yl)methyl](phenylmethyl)amino]propanenitrile

المردود 28.6%

المذيبات

2-propenenitrile

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةat reflux temperature
2. 2
   درجة الحرارةthe reaction mixture was cooled
3. 3
   ترشيحThe whole was filtered over diatomaceous earth
4. 4
   أخرىthe filtrate was evaporated

الإجراء التجريبي

3 ml of N,N,N-trimethylbenzenemethanaminium hydroxide was added dropwise to a stirred mixture of 60 g (±)-3,4-dihydro-N-(phenylmethyl)-2H-1-benzopyran-2-methanamine in 350 ml of 2-propenenitrile. After stirring for 4 days at reflux temperature, the reaction mixture was cooled and poured into 1,1'-oxybisethane. The whole was filtered over diatomaceous earth and the filtrate was evaporated, yielding 21 g (28.6%) of (±)-3-[[(3,4-dihydro-2H1-benzopyran-2-yl)methyl](phenylmethyl)amino]propanenitrile as crude residue (interm. 21).

المصدر