تفاعل #1062

معادلة التفاعل

compound ( 4 )

4-(4-phenoxyphenyl)piperidine

chloroacetonitrile

sodium iodide

potassium carbonate

→

compound ( 26 )

المردود 91.0%

1-cyanomethyl-4-(4-phenoxyphenyl)piperidine

المردود 91.0%

المذيبات

dimethylformamide

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThis was then heated
2. 2
   درجة الحرارةat reflux for 2 hours
3. 3
   استخلاصextraction
4. 4
   أخرىThe extract was dried
5. 5
   ترشيحfiltered
6. 6
   تركيزconcentrated under reduced pressure
7. 7
   أخرىto obtain a residue which
8. 8
   أخرىwas then purified by silica gel column chromatography (methylene chloride:methanol =30:1)

الإجراء التجريبي

To an 8 ml dimethylformamide solution of 300 mg of the compound (4) synthesized in Reference Example 4 were added 93 mg of chloroacetonitrile, 355 mg of sodium iodide, and 196 mg of potassium carbonate. This was then heated at reflux for 2 hours. To the reaction was added 10 ml of ice water, then extraction was performed with ethyl acetate. The extract was dried, filtered, then concentrated under reduced pressure to obtain a residue which was then purified by silica gel column chromatography (methylene chloride:methanol =30:1) to obtain the above-identified compound (26) in an amount of 313 mg (yield of 91%).

المصدر