تفاعل #1060135

معادلة التفاعل

3-hydroxy-2-butanone

ethyl acetoacetate

ethanol

→

2,4,5-trimethyl-3-furoic acid

المردود 96.0%

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwas heated
2. 2
   درجة الحرارةunder reflux for 24 hours
3. 3
   استخلاصextracted with benzene
4. 4
   استخلاصThe benzene extract
5. 5
   غسيلwas washed successively with 30% aqueous sodium bisulfite, 5% sodium hydroxide, dilute hydrochloric acid and finally with water
6. 6
   أخرىThe solvent was removed
7. 7
   أخرىto yield 149 g

الإجراء التجريبي

A mixture of 3-hydroxy-2-butanone (90g.) ethyl acetoacetate (175g.), absolute ethanol (150 ml.) and anhydrous zinc chloride (100g.) was heated under reflux for 24 hours. The cooled solution was poured into water and extracted with benzene. The benzene extract was washed successively with 30% aqueous sodium bisulfite, 5% sodium hydroxide, dilute hydrochloric acid and finally with water. The solvent was removed and the residual ester saponified with aqueous-alcoholic alkali as in example 18 to yield 149 g. or 96% yield of the 2,4,5-trimethyl-3-furoic acid.

المصدر