تفاعل #10596

معادلة التفاعل

Intermediate 17

N-[(1-amino-5-isoquinolyl)sulfonyl]-N′-(tert-butoxycarbonyl)-N-[2-(phenylsulfonyl)ethyl]ethylenediamine

hydrogen chloride methanol

→

title compound

N-[(1-amino-5-isoquinolyl)sulfonyl]-N-[2-(phenylsulfonyl)ethyl]ethylenediamine hydrochloride

المذيبات

diethyl ether

ظروف التفاعل

المعالجة

1. 1
   أخرى(50° C., 2 hours)
2. 2
   أخرىThe deposited precipitates
3. 3
   ترشيحwere collected by filtration
4. 4
   غسيلwashed with diethyl ether

الإجراء التجريبي

According to the method of Example 1, Step C, deprotection was performed (50° C., 2 hours) by using Intermediate 17 (134 mg) and 10% hydrogen chloride/methanol solution (2.5 ml). The reaction mixture was cooled to room temperature and then added with diethyl ether (2.5 ml). The deposited precipitates were collected by filtration and washed with diethyl ether to obtain the title compound (100 mg) as white powdery solid.

المصدر