تفاعل #10593

معادلة التفاعل

Intermediate 11

N-(tert-butoxycarbonyl)-N′-[(5-isoquinolyl)sulfonyl]-N′-[2-(phenylsulfonyl)ethyl]ethylenediamine

hydrogen chloride methanol

→

title compound

N-[(5-isoquinolyl)sulfonyl]-N-[2-(phenylsulfonyl)ethyl]ethylenediamine hydrochloride

ظروف التفاعل

المعالجة

1. 1
   أخرى(50° C., 2 hours)
2. 2
   أخرىthe solvent was evaporated under reduced pressure
3. 3
   workup.ADDITIONThe residue was added with methanol (1 ml) and diethyl ether (3 ml)
4. 4
   أخرىThe deposited precipitates
5. 5
   ترشيحwere collected by filtration
6. 6
   غسيلwashed with diethyl ether

الإجراء التجريبي

According to the method of Example 1, Step C, deprotection was performed (50° C., 2 hours) by using Intermediate 11 (260 mg) and 10% hydrogen chloride/methanol solution (5 ml). The reaction mixture was cooled to room temperature, and then the solvent was evaporated under reduced pressure. The residue was added with methanol (1 ml) and diethyl ether (3 ml). The deposited precipitates were collected by filtration and washed with diethyl ether to obtain the title compound (197 mg) as white powdery solid.

المصدر