تفاعل #10588

معادلة التفاعل

Intermediate 2

N-(tert-butoxycarbonyl)-N′-[(5-isoquinolyl)sulfonyl]-N′-(3-phenylpropyl)-1,3-propylenediamine

hydrogen chloride methanol

→

title compound

N-[(5-isoquinolyl)sulfonyl]-N-(3-phenylpropyl)-1,3-propylenediamine hydrochloride

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةunder reflux
2. 2
   درجة الحرارةby heating
3. 3
   أخرىAfter the reaction
4. 4
   أخرىthe solvent was evaporated under reduced pressure
5. 5
   أخرىthe residue was crystallized from a mixed solvent of methanol and diethyl ether

الإجراء التجريبي

Intermediate 2 (913 mg) was added with 10% hydrogen chloride/methanol solution (18 ml, Tokyo Kasei Kogyo) at room temperature and stirred for 25 minutes under reflux by heating. After the reaction, the solvent was evaporated under reduced pressure, and the residue was crystallized from a mixed solvent of methanol and diethyl ether to obtain the title compound (653 mg).

المصدر