تفاعل #1057166

معادلة التفاعل

product

N-[4′-(1-azabicyclo[2.2.2]oct-3-yloxy)-1,1′-biphenyl-4-yl]-N-phenylamine

ethanol

fumaric acid

→

title compound

N-[4′-(1-azabicyclo[2.2.2]oct-3-yloxy)-1,1′-biphenyl-4-yl]-N-phenylamine fumarate

المذيبات

ethyl acetate

ظروف التفاعل

الإجراء التجريبي

The product of Example 11A (200 mg, 0.54 mmol) in ethyl acetate:ethanol (5 mL, 1:1) was treated with fumaric acid (70 mg, 0.6 mmol). The title compound was obtained as a solid (197.8 mg, yield, 72%). 1H NMR (MeOH-d4, 300 MHz) δ 1.81-2.20 (m, 3H), 2.27-2.42 (m, 1H), 2.50-2.58 (m, 1H), 3.17-3.48 (m, 5H), 3.75-3.87 (m, 1H), 4.85-4.93 (m, 1H), 6.71 (s, 2.5H), 6.81-6.89 (m, 1H), 7.02 (d, J=8.8 Hz, 2H), 7.07-7.17 (m, 4H), 7.18-7.27 (m, 2H), 7.45 (d, J=8.8 Hz, 2H), 7.54 (d, J=8.8 Hz, 2H) ppm. MS (DCl/NH3) m/z 371 (M+H)+. Anal. Calculated for C25H26N2O.1.2C4H4O4: C, 70.21; H, 6.09; N, 5.50. Found: C, 70.09; H, 6.17; N, 5.43.

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