تفاعل #1055865

معادلة التفاعل

3-(3-dimethylamino-acryloyl)-benzonitrile

phenylguanidine

→

title compound

3-(2-Phenylamino-pyrimidin-4-yl)-benzonitrile

المذيبات

acetonitrile

acetonitrile

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةthe mixture was heated
2. 2
   درجة الحرارةat reflux for two hours
3. 3
   درجة الحرارةThe solution was cooled
4. 4
   ترشيحthe resulting solid was filtered
5. 5
   غسيلwashed with acetonitrile

الإجراء التجريبي

To a solution of 3-(3-dimethylamino-acryloyl)-benzonitrile (30.4 g, 152 mmol) in acetonitrile (250 mL) was added a solution of phenylguanidine (21.0 g, 155 mmol) in acetonitrile (250 mL) and the mixture was heated at reflux for two hours. The solution was cooled and the resulting solid was filtered and washed with acetonitrile to afford the title compound.

المصدر