تفاعل #1053706

معادلة التفاعل

5-(2-methanesulfonyloxy-ethyl)-2-methyl-1H-indole-3-carboxylic acid benzyl ester

pyrrolidine

→

desired product

المردود 91.0%

2-Methyl-5-(2-pyrrolidin-1-yl-ethyl)-1H-indole-3-carboxylic acid benzyl ester

المردود 91.0%

المذيبات

dioxane

ظروف التفاعل

المعالجة

1. 1
   تركيزwas concentrated in vacuo
2. 2
   أخرىto give a residue, which
3. 3
   أخرىwas purified by chromatography (5%-15% methanol in methylene chloride)

الإجراء التجريبي

To a solution of 5-(2-methanesulfonyloxy-ethyl)-2-methyl-1H-indole-3-carboxylic acid benzyl ester (100 mg, 0.26 mmol) in dioxane (5 mL) was added pyrrolidine (0.2 mL, 2.6 mmol). The mixture was stirred at 70° C. for 1 hour and then was concentrated in vacuo to give a residue, which was purified by chromatography (5%-15% methanol in methylene chloride) to give 85 mg (91%) of the desired product as a thick oil: MS(APCI+): m/z 363.2 (MH+).

المصدر