تفاعل #10537

معادلة التفاعل

methyl 9-{(2R,3R,4R,5S)-3,4-bis(benzoyloxy)-5-[(ethylamino)carbonyl]-tetrahydro-2-furanyl}-6-[(2,2-diphenylethyl)amino]-9H-purine-2-carboxylate

sodium carbonate

→

title compound

المردود 98.0%

Methyl 6-[(2,2-diphenylethyl)amino]-9-{(2R,3R,4S,5S)-5-[(ethylamino)carbonyl]-3,4-dihydroxytetrahydro-2-furanyl}-9H-purine-2-carboxylate

المردود 98.0%

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   أخرىSolvent was removed under reduced pressure
2. 2
   workup.ADDITIONthe residue taken up in a mixture of dichloromethane:methanol (95:5, by volume, 60 ml)
3. 3
   ترشيحInorganic salts were filtered off
4. 4
   أخرىthe filtrate evaporated under reduced pressure
5. 5
   أخرىThe residue was triturated with diethyl ether
6. 6
   ترشيحfiltered off
7. 7
   أخرىdried

الإجراء التجريبي

A solution of methyl 9-{(2R,3R,4R,5S)-3,4-bis(benzoyloxy)-5-[(ethylamino)carbonyl]-tetrahydro-2-furanyl}-6-[(2,2-diphenylethyl)amino]-9H-purine-2-carboxylate (Preparation 8) (3.4 g, 4.5 mmol) and sodium carbonate (50 mg) in dry methanol (60 ml) was stirred at room temperature for four hours. Solvent was removed under reduced pressure and the residue taken up in a mixture of dichloromethane:methanol (95:5, by volume, 60 ml). Inorganic salts were filtered off and the filtrate evaporated under reduced pressure. The residue was triturated with diethyl ether, filtered off and dried to yield the title compound as a white solid, (2.4 g, 98%).

المصدر