تفاعل #1053653

معادلة التفاعل

5-(2-chloro-ethoxy)-2-methyl-1H-indole-3-carboxylic acid benzyl ester

5-(2-Chloro-ethoxy)-2-methyl-1H-indole-3-carboxylic acid benzyl ester

sodium iodide

→

5-(2-iodo-ethoxy)-2-methyl-1H-indole-3-carboxylic acid benzyl ester

المذيبات

2-butanone

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe solution was heated
2. 2
   درجة الحرارةat reflux for 48 hours
3. 3
   تركيزconcentrated

الإجراء التجريبي

To a solution of 5-(2-chloro-ethoxy)-2-methyl-1H-indole-3-carboxylic acid benzyl ester (0.873 mmol, 0.300 g, Example 1, Step A) in 10 mL of 2-butanone was added sodium iodide (8.73 mmol, 1.31 g). The solution was heated at reflux for 48 hours, cooled to room temperature, and concentrated to afford the crude product, 5-(2-iodo-ethoxy)-2-methyl-1H-indole-3-carboxylic acid benzyl ester: MS(APCI+): m/z 436.0 (M+1).

المصدر