تفاعل #1053263

ord-d8a09ee187274df09e14147d1f7d7216

معادلة التفاعل

COC(=O)c1ccccc1NC(=O)N[C@H]1COC(C)(C)O[C@H]1c1ccccc1
product
COC(=O)c1ccccc1NC(=O)N[C@H]1COC(C)(C)O[C@H]1c1ccccc1
2-[3-((4S,5S)-2,2-Dimethyl-4-phenyl-[1,3]dioxan-5-yl)-ureido]-benzoic acid methyl ester
[Li+].[OH-]
lithium hydroxide
→
CC1(C)OC[C@H](NC(=O)Nc2ccccc2C(=O)O)[C@H](c2ccccc2)O1
title compound
CC1(C)OC[C@H](NC(=O)Nc2ccccc2C(=O)O)[C@H](c2ccccc2)O1
2-[3-((4S,5S)-2,2-Dimethyl-4-phenyl-[1,3]dioxan-5-yl)-ureido]-benzoic acid

المتفاعلات

COC(=O)c1ccccc1NC(=O)N[C@H]1COC(C)(C)O[C@H]1c1ccccc1
product
COC(=O)c1ccccc1NC(=O)N[C@H]1COC(C)(C)O[C@H]1c1ccccc1
2-[3-((4S,5S)-2,2-Dimethyl-4-phenyl-[1,3]dioxan-5-yl)-ureido]-benzoic acid methyl ester
[Li+].[OH-]
lithium hydroxide

الكواشف

لا شيء

المذيبات

C1CCOC1
THF

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

الإجراء التجريبي

The title compound was prepared upon treatment of the product of Example 40 with lithium hydroxide in aqueous THF.

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US06951882B2uspto-grants-2005_10