تفاعل #1053257

معادلة التفاعل

product

1-(2-Bromo-phenyl)-3-((4S,5S)-2,2-dimethyl-4-phenyl-[1,3]dioxan-5-yl)-urea

dimethylacetamide

→

title compound

1-(2-Cyano-phenyl)-3-((4S,5S)-2,2-dimethyl-4-phenyl-[1,3]dioxan-5-yl)-urea

المذيبات

ethyl acetate

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe reaction mixture was cooled to room temperature
2. 2
   غسيلThe organic layer was washed with water
3. 3
   أخرىseparated
4. 4
   تجفيفdried over anhydrous sodium sulfate
5. 5
   ترشيحfiltered
6. 6
   تركيزThe filtrate was concentrated in vacuo

الإجراء التجريبي

A mixture of the product from Example 19 (355 mg, 0.88 mmol), tetrakis(triphenylphosphine)palladium(0) (102 mg, 10 mol %) and zinc cyanide (103 mg, 0.88 mmol) in dimethylacetamide (8.0 mL) was heated at 80° C. for 8 h. The reaction mixture was cooled to room temperature and diluted with ethyl acetate (25 mL). The organic layer was washed with water, separated, dried over anhydrous sodium sulfate, and filtered. The filtrate was concentrated in vacuo to afford 309 mg of the title compound.

المصدر