تفاعل #1053252

معادلة التفاعل

(4S,5S)-amine

(4S,5S)-2,2-dimethyl-4-phenyl-1,3-dioxan-5-amine

2,4-dichlorophenyl isocyanate

→

title compound

المردود 59.0%

1-(2,4-Dichloro-phenyl)-3-((4S,5S)-2,2-dimethyl-4-phenyl-[1,3]dioxan-5-yl)-urea

المردود 59.0%

المذيبات

pentane

dichloromethane

ظروف التفاعل

المعالجة

1. 1
   ترشيحcollected via filtration
2. 2
   workup.DISSOLUTIONThe crude solid was dissolved in dichloromethane (˜4 mL)
3. 3
   غسيلwashed with 0.1 N HCl (˜4 mL)
4. 4
   غسيلThe organic layer was washed with brine
5. 5
   تجفيفdried over magnesium sulfate
6. 6
   ترشيحfiltered
7. 7
   أخرىevaporated

الإجراء التجريبي

To a solution of 102 mg (0.49 mmol) of (4S,5S)-amine 1 in pentane (3 mL) was added a solution of 74 mg (0.39 mmol) of 2,4-dichlorophenyl isocyanate in dichloromethane (0.1 mL). A white precipitate was observed and collected via filtration. The crude solid was dissolved in dichloromethane (˜4 mL) and washed with 0.1 N HCl (˜4 mL). The organic layer was washed with brine, dried over magnesium sulfate, filtered, and evaporated to yield 91 mg (59%) of the title compound.

المصدر