تفاعل #1051940

معادلة التفاعل

serotonin creatinine sulfate monohydrate

N-carbethoxyphthalimide

potassium carbonate

→

title compound

5-Hydroxy-3-(2-phthalimidoethyl)-1H-indole

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe precipitate was filtered
2. 2
   غسيلwashed with water
3. 3
   أخرىdried

الإجراء التجريبي

To a suspension of serotonin creatinine sulfate monohydrate (5 g, 12.333 mmol) in water (80 mL) were added N-carbethoxyphthalimide (2.84 g, 1.30 mmol) and potassium carbonate (3.54 g, 24.6 mmol). The resulting mixture was stirred at room temperature for 4 hours. The precipitate was filtered, washed with water and dried to give the title compound (3.8 g, 100%) as a yellow solid. 1H NMR (CD3SOCD3, 300 MHz) δ: 10.52 (s, 1H), 8.64 (s, 1H), 7.87-7.83 (A2B2 system, 4H), 7.12 (d, J=8.6 Hz, 1H), 7.08 (broad s, 1H), 6.89 (broad s, 1H), 6.60 (broad d, J=8.6 Hz, 1H).

المصدر