تفاعل #1045

معادلة التفاعل

2,3,3-trifluoro-2-propenyl bromide

triethyl phosphite

→

diethyl (1,1,2-trifluro-2-propenyl)phosphonate

المردود 11.0%

diethyl (2,3,3-trifluro-2-propenyl)phosphonate

المردود 14.0%

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةat reflux for overnight
2. 2
   أخرىThe residue obtained
3. 3
   أخرىafter evaporation of the solvent
4. 4
   أخرىwas chromatographed over silica gel (hexanes/ethyl acetate/ethanol, 80/20/1)

الإجراء التجريبي

A solution of 2,3,3-trifluoro-2-propenyl bromide (5.25 g, 30 mmol) and triethyl phosphite (4.15 g, 25 mmol) in acetonltrile (15 mL) was heated at reflux for overnight. The residue obtained after evaporation of the solvent was chromatographed over silica gel (hexanes/ethyl acetate/ethanol, 80/20/1) to give diethyl (1,1,2-trifluro-2-propenyl)phosphonate (0.8 g, 11%) and diethyl (2,3,3-trifluro-2-propenyl)phosphonate (1.0 g, 14%).

المصدر