تفاعل #1044

معادلة التفاعل

1,2,4-triazole

3,4,4-trifluoro-3-butenoyl chloride

→

desired product

المردود 94.2%

1-(3,4,4-trifluoro-1-oxo-3-butenyl)-1H-1,2,4-triazole

المردود 94.2%

المذيبات

ethyl acetate

ظروف التفاعل

المعالجة

1. 1
   workup.STIRRINGThe mixture was stirred for 30 min
2. 2
   ترشيحfiltered
3. 3
   أخرىThe residue obtained
4. 4
   أخرىafter evaporation of the solvent
5. 5
   workup.DISSOLUTIONwas redissolved in dichloromethane (25 mL)
6. 6
   ترشيحfiltered
7. 7
   أخرىEvaporation of the solvent

الإجراء التجريبي

To a solution of 1,2,4-triazole (1.38 g, 20 mmol) in ethyl acetate (100 mL) was added 3,4,4-trifluoro-3-butenoyl chloride (1.59 g, 10 mmol) at r.t. with stirring. The mixture was stirred for 30 min and filtered. The residue obtained after evaporation of the solvent was redissolved in dichloromethane (25 mL) and filtered. Evaporation of the solvent gave 1.8 g (94%) of the desired product as a dear oil.

المصدر