تفاعل #1042

معادلة التفاعل

3,4,4-trifluoro-3-butenoyl chloride

2-amino-4,6-dimethoxypyrimidine

potassium carbonate

→

title compound

المردود 10.7%

2-(3,4,4-trifluoro-1-oxo-3-butenyl)amino-4,6-dimethoxy-pyrimidine

المردود 10.7%

المذيبات

dichloromethane

water

ظروف التفاعل

المعالجة

1. 1
   workup.STIRRINGThe reaction mixture was stirred in cold for 10 min
2. 2
   غسيلThe organic layer was washed with 3N HCl (2×25 mL), saturated sodium bicarbonate (25 mL) and brine
3. 3
   أخرىdried
4. 4
   أخرىEvaporation of the solvent

الإجراء التجريبي

To an ice-cooled stirred suspension of 2-amino-4,6-dimethoxypyrimidine (1.55 g, 10 mmol) in dichloromethane (50 mL) and potassium carbonate (2.76 g, 20 mmol) in water (20 mL) was added 3,4,4-trifluoro-3-butenoyl chloride (3.17 g, 20 mmol). The reaction mixture was stirred in cold for 10 min and at r.t. for 15 min. The organic layer was washed with 3N HCl (2×25 mL), saturated sodium bicarbonate (25 mL) and brine, and dried. Evaporation of the solvent gave 0.296 g (10%) of the title compound as a white solid. m.p. 127°-130° C.

المصدر