تفاعل #10409

معادلة التفاعل

2-Amino-4,5-difluorobenzoic acid, 2,2-dibenzylhydrazide

triphosgene

NaHCO3

→

title compound

المردود 198.7%

3-Dibenzylamino-6,7-difluoro-1H-quinazoline-2,4-dione

المردود 198.7%

المذيبات

methylene chloride

ظروف التفاعل

المعالجة

1. 1
   أخرىthe layers are separated
2. 2
   غسيلthe aqueous layer is washed three times with ethyl acetate
3. 3
   تجفيفThe combined organic layers are dried over magnesium sulfate
4. 4
   تركيزconcentrated

الإجراء التجريبي

2-Amino-4,5-difluorobenzoic acid, 2,2-dibenzylhydrazide (Example 15) (0.81 g, 2.2 mmol) and triphosgene (0.33 g, 1.1 mmol) are combined in 100 mL of methylene chloride and stirred at 25° C. for 20 hours. The solution is poured into 200 mL of saturated NaHCO3, the layers are separated, and the aqueous layer is washed three times with ethyl acetate. The combined organic layers are dried over magnesium sulfate and then concentrated to give 0.86 g of the title compound as a solid. MS CI: m/z 394 (MH+).

المصدر