تفاعل #10350

معادلة التفاعل

4,6-Dichloro-5-(o-methoxyphenoxy)-2-(4-pyridyl)-pyrimidine

ammonia

ammonia

→

4-amino-6-chloro-5-(o-methoxyphenoxy)-2-(4-pyridyl)-pyrimidine

المذيبات

dioxane

ظروف التفاعل

المعالجة

1. 1
   أخرىThe solvent was evaporated
2. 2
   workup.ADDITIONwater was added to the residue
3. 3
   ترشيحthe precipitate was filtered off
4. 4
   أخرىAfter drying at HV/50° C

الإجراء التجريبي

4,6-Dichloro-5-(o-methoxyphenoxy)-2-(4-pyridyl)-pyrimidine (2.9 g, Referential Example 1d)) was suspended in dioxane (30 ml) and ammonia (gaseous) was introduced until the solution was saturated. Stirring was continued for 7 days while the saturation of the reaction mixture with ammonia (gaseous) was repeated every 16 to 20 h. The solvent was evaporated, water was added to the residue and the precipitate was filtered off. After drying at HV/50° C. 4-amino-6-chloro-5-(o-methoxyphenoxy)-2-(4-pyridyl)-pyrimidine (2.7 g) was obtained.

المصدر