تفاعل #10333

معادلة التفاعل

diethylether

ammoniumchloride

sodium

4-cyanopyridine

→

4-Amidino-pyridine hydrochloride

المردود 93.0%

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   workup.STIRRINGstirring
2. 2
   workup.WAITwas continued for another 10 h
3. 3
   ترشيحthe precipitate was filtered off after 30 min
4. 4
   غسيلwashed with diethylether (20 ml)
5. 5
   أخرىThe product was dried under high vacuum

الإجراء التجريبي

To a solution of sodium (0.23 g) in methanol (40 ml) was added 4-cyanopyridine (10.62 g) at r.t. Stirring was continued for 6 h followed by the addition of ammoniumchloride (5.9 g) and stirring was continued for another 10 h. Then, diethylether (120 ml) was added and the precipitate was filtered off after 30 min and washed with diethylether (20 ml). The product was dried under high vacuum. 4-Amidino-pyridine hydrochloride (14.95 g) was obtained as a white powder.

المصدر