تفاعل #10269

معادلة التفاعل

[5-((morpholin-4-yl)methyl)-4,5-dihydro-isoxazol-3-yl]methyl 2-tetrahydropyranyl ether

pyridinium p-toluenesulfonate

→

[5-((morpholin-4-yl)methyl)-4,5-dihydro-isoxazol-3-yl]methanol

المردود 95.0%

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwas heated
2. 2
   درجة الحرارةunder reflux for 24 h
3. 3
   أخرىwas removed in vacuo
4. 4
   أخرىthe residue purified by flash chromatography (SiO2, CH2Cl2/MeOH/NH4OH 92/7.5/0.5)

الإجراء التجريبي

A mixture of [5-((morpholin-4-yl)methyl)-4,5-dihydro-isoxazol-3-yl]methyl 2-tetrahydropyranyl ether (0.63 g) with pyridinium p-toluenesulfonate (10 mol %) in methanol was heated under reflux for 24 h. After cooling to room temperature the solvent was removed in vacuo and the residue purified by flash chromatography (SiO2, CH2Cl2/MeOH/NH4OH 92/7.5/0.5) to afford [5-((morpholin-4-yl)methyl)-4,5-dihydro-isoxazol-3-yl]methanol (95%). Rf 0.17 (CH2Cl2/MeOH/NH4OH 92/7.5/0.5).

المصدر