تفاعل #10267

معادلة التفاعل

NaOH

acetaldehyde

O-[2-((morpholin-4-yl))ethyl]hydroxylamine dihydrochloride

NaOH

→

2-chloroethanal O-[2-((morpholin-4-yl))ethyl]oxime

المردود 100.0%

المذيبات

water

water

ظروف التفاعل

المعالجة

1. 1
   استخلاصextracted with dichloromethane
2. 2
   تجفيفThe organic layer was dried (Na2SO4)
3. 3
   تركيزconcentrated in vacuo

الإجراء التجريبي

A mixture of acetaldehyde (0.1 mL of a 50 wt % soln. in water), O-[2-((morpholin-4-yl))ethyl]hydroxylamine dihydrochloride (0.14 g), NaOH (2N, 0.64 mL) and water (5 mL) was stirred at room temperature overnight. The solution was made basic with NaOH (1N) and extracted with dichloromethane. The organic layer was dried (Na2SO4), and concentrated in vacuo to afford 2-chloroethanal O-[2-((morpholin-4-yl))ethyl]oxime (0.13 g, ˜100%), which was used as such.

المصدر