تفاعل #1023

معادلة التفاعل

2-amino-1-propanol

sodium hydride

4-chloropyridine hydrochloride

→

desired product

المردود 30.2%

1-methyl-2-(4-pyridyloxy)ethylamine

المردود 30.2%

المذيبات

N,N-dimethylformamide

ظروف التفاعل

المعالجة

1. 1
   workup.STIRRINGThe mixture was stirred for 20 hours at room temperature
2. 2
   أخرىAfter completion of the reaction
3. 3
   ترشيحthe solids were filtered off
4. 4
   أخرىThe solvent in the filtrate was removed under reduced pressure
5. 5
   أخرىThe residue was purified by column chromatography on silica gel

الإجراء التجريبي

6.2 g of 2-amino-1-propanol was added dropwise to a stirred mixture of 4.0 g of 60% sodium hydride and 50 mL of N,N-dimethylformamide at 5° C.-10° C. After the reaction mixture was stirred for 30 minutes, 12.5 g of 4-chloropyridine hydrochloride in limited amounts was added to the reaction mixture. The mixture was stirred for 20 hours at room temperature. After completion of the reaction, the solids were filtered off. The solvent in the filtrate was removed under reduced pressure. The residue was purified by column chromatography on silica gel to obtain 3.8 g of the desired product (yield: 30%). Refractive index: 1.5469.

المصدر