تفاعل #10206

معادلة التفاعل

3,3-Dimethoxypropanoic acid methyl ester

LiOH.H2O

H2O

→

solids

المردود 98.7%

3,3-Dimethoxypropanoic acid lithium salt

المردود 98.7%

المذيبات

THF

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةto reflux for 4 hours
2. 2
   تجفيفazeotropically dried from THF (4 times)

الإجراء التجريبي

(Related to methods described in Alabaster, C. T. et. al., J. Med. Chem. 1988, 31, 2048–2056.) 3,3-Dimethoxypropanoic acid methyl ester (14.25 g, 96.2 mmol) in THF (100 mL) was treated with LiOH.H2O (2.5 g, 106 mmol) and H2O (2 mL). The mixture was brought to reflux for 4 hours, cooled to room temperature and azeotropically dried from THF (4 times) to provide white solids (13.3 g).

المصدر