تفاعل #1011002

معادلة التفاعل

sodium hydroxide

3,5-Dibromo-2-hydroxybenzaldehyde

4-methoxyphenylacetic acid

triethylamine

→

6,8-Dibromo-3-(4-methoxy-phenyl)-chromen-2-one

المذيبات

acetic anhydride

ظروف التفاعل

المعالجة

1. 1
   ترشيحAfter 5 min the precipitated product is filtered by vacuum
2. 2
   غسيلwashed with water

الإجراء التجريبي

3,5-Dibromo-2-hydroxybenzaldehyde (30.0 g, 107 mmol) [CAS-Nr. 90-59-5] and 4-methoxyphenylacetic acid (35.7 g, 166 mmol) are heated in 51 ml acetic anhydride and 60 ml triethylamine overnight at reflux. The reaction mixture is cooled down to 80° C. and poured onto 1000 ml 2 M sodium hydroxide under stirring. After 5 min the precipitated product is filtered by vacuum, washed with water and digested two times with 100 ml ethanol. 6,8-Dibromo-3-(4-methoxy-phenyl)-chromen-2-one is obtained as a yellow solid.

المصدر