تفاعل #1008794

معادلة التفاعل

Methyl 4-hydroxy-3-nitrobenzoate

NBS

→

Methyl 3-bromo-4-hydroxy-5-nitrobenzoate

المردود 95.3%

المذيبات

acetic acid

ظروف التفاعل

المعالجة

1. 1
   أخرىThe mixture was quenched with water
2. 2
   ترشيحthe suspension was filtered

الإجراء التجريبي

(I4A): Methyl 4-hydroxy-3-nitrobenzoate (15 g, 76 mmol) was suspended in acetic acid (152 ml) and then treated with NBS (20.31 g, 114 mmol). The mixture became a homogeneous yellow solution which was stirred for 2 h. The mixture was quenched with water and the suspension was filtered. Methyl 3-bromo-4-hydroxy-5-nitrobenzoate (20 g) was obtained as a yellow solid.

المصدر